Cialis is the long-acting erectile dysfunction (ED) medication – up to 36 hours. It contains tadalafil as its active ingredient. This pill works by enhancing the effects of nitric oxide (NO) & cyclic guanosine monophosphate (cGMP). It stimulates cGMP production by interacting with the haem group of the enzyme called soluble guanylate cyclase (sGC). This interaction empowers sGC to convert GTP into cGMP.
To achieve the mechanism, Cialis must inhibit the phosphodiesterase type 5 (PDE5) enzyme from breaking down the release of NO when a man is sexually aroused. This synergy allows for enhanced blood flow into the penis needed to trigger an erection.
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